學習經歷
2004-2008 EON体育4，學士
2008-2011 蘭州大學，有機化學碩士
2014-2019 清華大學，生物學博士
工作經歷
2011-2012 重慶科學技術研究院生物醫藥研究中心
2012-2014 中國樂凱集團有限公司研究院
2019- EON体育4，校聘教授
教學工作
本科生課程：
1.基礎課《藥物化學》、《天然藥物化學》
2.專業選修課《藥物設計與合成》
主要研究方向及領域
1.基於生物活性導向的藥物合成🔦；
2.抗微生物藥物的發現。
主持課題項目
1.國家自然科學基金🤹♂️，靶向膽固醇代謝途徑抗流感抑製劑的發現及作用機製研究，2021-2024🤟⁉️，22077026，主持
2.河北省自然科學基金，靶向人的類異戊二烯途徑抑製劑影響流感病毒出芽的作用機製研究🏌🏽🙎🏻♀️，2020-2022𓀐，H2020204002,主持
出版教材著作
代表性學術成果
研究論文（*通訊作者）：
1.Li Dong, Xiaoqing Wang, Gou Yanhui, Shuo Yu, Zhengsen Yu*, Photoredox/HAT-Catalyzed Intramolecular Hydrocyclization of Alkenes toward 2, 3-Fused Quinazolinones and Dihydroquinazolinones, Organic Letters, 2024, 26, 8756-8761.
2.Zhiyuan Bao, Yifei. Li, Ruitong Zhang, Zhengsen Yu, Chao Chen*, Electrophilic aryl spiroannulation induced by diaryliodonium salts: efficient synthesis of [5,5]-spiro lactone-lactam scaffolds from α-cyanocarboxylates, Green Synthesis and Catalysis, 2024.
3.Dong Li, Xiaoqing Wang, Yudi Nie, Shuo Yu, Haotong Li, Qian Zhao, Zhengsen Yu*, Regioselective Perfluoroalkylation of 4-Quinolones Using Sodium Perfluoroalkyl Sulfinates, European Journal of Organic Chemistry, 2022, 37, e202200842.
4.Fang Yang, Xiaoqing Wang, Wenzhuo Zhao, Fei Yu and Zhengsen Yu*, Hypervalent Iodine (III)-Promoted C3–H Regioselective Halogenation of 4-Quinolones under Mild Conditions, ACS omega, 2021, 6(49): 34044-34055.
5.Rong Xiang#, Zhengsen Yu#, Yang Wang#, Lili Wang, Shanshan Huo, Yanbai Li, Riying Liang, Qinghong Hao, Yaning Gao*, Fei Yu* and Shibo Jiang*, Recent Advances in Developing Small-molecule Inhibitors against SARS-CoV-2. Acta Pharmaceutica Sinica B, 2021, 12(4), 1591-1623.
6.Shuai Han, Xin Li, Xia Yun, Zhengsen Yu, Ningning Cai, Satich R. Malwal, Xu Han, Eric Oldfield*, Yonghui Zhang*, Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells, Journal of Medicinal Chemistry, 2019, 62 (23): 10867-10896.
7.Yun Xia#, Yonghua Xie#, Zhengsen Yu#, Hongying Xiao, Guimei Jiang, Xiaoying Zhou, Yunyun Yang, Xin Li, Meng Zhao, Liping Li, Mingke Zheng, Shuai Han, Zhaoyun Zong, Xianbin Meng, Haiteng Deng, Huahu Ye, Yunzhi Fa, Haitao Wu, Eric Oldfield, Xiaoyu Hu, Wanli Liu*, Yan Shi*, and Yonghui Zhang*, The Mevalonate Pathway is a Druggable Target for Vaccine Adjuvant Discovery, Cell, 2018, 175 (4), 1059-1073.
發明專利：
於正森;王小清;孟許峰;湯建誌;於碩;董力. C-3全氟烷基化4-喹啉酮類化合物的製備方法. ZL 2022 1 1133591.0, 2022-09-08.
