於正森 （教授/碩士生導師）
研究方向𓀆：抗感染藥物設計、合成；生物活性天然化合物的提取、分離
聯系方式：yuzhengsen@hebau.edu.cn
| 榮譽稱號
太行學者三層次引進
| 主講課程
微生物藥物學、藥物合成
| 教育背景
2004-2008年 EON体育4 本科
2008-2011年 蘭州大學功能有機化學國家重點實驗室 碩士
2014-2019年 清華大學藥EON4 生物學博士
| 主持課題
1. 國家自然科學基金1項，2021.1-2024.12，63萬
2. 河北省自然科學基金1項，2020.1-2022.12 🌗💂🏽，10萬
3. EON体育4人才引進1項，2019.12-2024.12，30萬
| 代表性學術成果
2018年9月，在CELL期刊發表《甲羥戊酸通路是新的疫苗佐劑製藥靶點》的藥學研究論文🧖🏻♂️，並揭示詳細的分子機製。基於甲羥戊酸激酶缺乏症這一罕見病🧍🏻♂️，我們首次提出並證實甲羥戊酸通路是可以作為佐劑開發的代謝通路，作用於該通路的疫苗佐劑在小鼠流感、癌症模型中顯示出較現用鋁佐劑更好的保護效果。
發明專利🧜🏻：
1. 申請中🌄：CN202110478872.9，一種wittig-hornor試劑的製備方法，發明人：於正森，王小清🧑🏽🏫、於飛🙋🏼♀️，楊芳🧚，趙文卓👨🏼。
2. 申請中☞👮🏻♂️：CN108289902，作為高效的疫苗佐劑的甲羥戊酸通路抑製劑，發明人🧘🏻：張永輝，夏赟❗️🫸，謝永華，於正森，周曉英🖖🏽，李鑫，李麗平，楊雲雲，高看照，王科🤟🏽，劉萬裏🔉，趙萌🧻。
3. 申請中♤：CN109666637，Vγ9Vδ2 T及其激動劑在治療肝纖維化🧑🦯🤓、肝硬化和肝癌中的應用😦，發明人⛏：張永輝，周曉英🍓，肖鴻穎🚣🏿，李麗平，謝永華，於正森👸。
4. 申請中🐸：WO2019076269A1，甲羥戊酸通路抑製劑及其藥物組合物👍，發明人↖️：張永輝，周曉英👨🏿🎨，肖鴻穎，夏赟，謝永華🩶，於正森。
近期論文：
1. Xiaoqian Deng#, ShijunTian#, ZhengsenYu#, LiliWang, RuiyingLiang, YanbaiLi, RongXiang, ShiboJiang*, TianleiYing*, FeiYu*, Development of Small-molecule Inhibitors Against Hantaviruses, Microbes and Infection, 2020, 22, 272-277 (First co-author, IF = 2.373, 3區).
2. Shuai Han, Xin Li, Xia Yun, Zhengsen Yu, Ningning Cai, Satich R. Malwal, Xu Han, Eric Oldfield*, Yonghui Zhang*, Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells, Journal of Medicinal Chemistry, 2019, 62 (23): 10867-10896 (IF = 6.253, 2區Top).
3. Yun Xia#, Yonghua Xie#, Zhengsen Yu#, Hongying Xiao, Guimei Jiang, Xiaoying Zhou, Yunyun Yang, Xin Li, Meng Zhao, Liping Li, Mingke Zheng, Shuai Han, Zhaoyun Zong, Xianbin Meng, Haiteng Deng, Huahu Ye, Yunzhi Fa, Haitao Wu, Eric Oldfield, Xiaoyu Hu, Wanli Liu*, Yan Shi*, and Yonghui Zhang*, The Mevalonate Pathway is a Druggable Target for Vaccine Adjuvant Discovery, Cell, 2018, 175 (4), 1059-1073 (First co-author, IF = 36.216, 1區Top).
4. Chunchi Chen, Xiangying Hu, Xueke Tang, Yunyun Yang, Tzu Ping Ko, Jian Gao, Yingying Zheng, Jianwen Huang, Zhengsen Yu, Liping Li, Shuai Han, Ningning Cai, Yonghui Zhang, Weidong Liu, Rey-Ting Guo*, The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement, Angewandte Chemie, 2018, 130 (46): 15280-15284 (IF = 12.257, 1區Top).
5. Xianhao Liu, Lilin Hou, Jinfeng Wang, Bin Liu, Zhengsen Yu, Liqian Ma, Shaopeng Yang, Guangsheng Fu*, Plasmonic-enhanced Polymer Solar Cells with High Efficiency by Addition of Silver Nanoparticles of Different Sizes in Different Layers, Solar Energy, 2014, 110, 627-635 (IF = 4.674, 2區).
6. Zhengsen Yu, Lijuan Ma, Wei Yu*, Phenyliodine Bis(trifluoroacetate) Mediated Intramolecular Oxidative Coupling of Electron-Rich N-Phenyl Benzamides, Synlett., 2012, 10, 1534-1540 (IF = 2.418, 3區).
7. Zhengsen Yu, Xuhui Ju, Junyan Wang, Wei Yu*, Iodobenzene Mediated Intramolecular Oxidative Coupling of Substituted 4-Hydroxyphenyl-N-phenylbenzamides for the Synthesis of Spirooxindoles, Synthesis, 2011, 6, 860-866 (IF = 2.867, 3區).
8. Zhengsen Yu, Lijuan Ma, Wei Yu*, Ag2O-Mediated Intramolecular Oxidative Coupling of Acetoacetanilides for the Synthesis of 3-Acetyloxindoles, Synlett., 2010, 17, 2607-2610 (IF = 2.418, 3區).
9. Junyan Wang, Xianpei Wang, Zhengsen Yu, Wei Yu*, The Synthesis of Polysubstituted Pyrroles via the Coupling of Phenyliodonium Ylides and Enamine Esters, Adv. Syn & Cata., 2009, 351 (13), 2063-2066 (IF = 5.1, 2區Top).
